Output of liver fatty acid-binding protein (L-FABP) in bile
Identifieur interne : 000111 ( France/Analysis ); précédent : 000110; suivant : 000112Output of liver fatty acid-binding protein (L-FABP) in bile
Auteurs : Laurent Foucaud [France] ; Joël Grillasca [France] ; Isabelle Niot [France] ; Nicole Domingo [France] ; Huguette Lafont [France] ; Richard Planells [France] ; Philippe Besnard [France]Source :
- BBA - Molecular and Cell Biology of Lipids [ 1388-1981 ] ; 1998.
Abstract
Liver fatty acid-binding protein (L-FABP) is a small cytoplasmic molecule highly expressed in the liver. Since L-FABP exhibits affinities for several biliary components, its presence in bile was explored by Western blotting and competitive ELISA in various mammalian species. A L-FABP-like immunoreactivity was consistently found in both hepatic and gallbladder bile. A close molecular identity between this 14 kDa biliary protein and the purified L-FABP was assessed by immunological analyses and high performance capillary electrophoresis. Pharmacological induction of hepatic L-FABP biosynthesis led to a similar increase in biliary L-FABP levels showing a close relationships between the cytosolic and biliary contents of this protein. Finally, a correlation between the presence of L-FABP in bile and both bile flow and bile acid release was found. These data suggest an output of L-FABP in bile in normal conditions which might be coupled with the physiological release of biliary components.
Url:
DOI: 10.1016/S0005-2760(98)00171-4
Affiliations:
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ISTEX:54AACECDE74BEA4445121A0073BAC60680CDAA30Le document en format XML
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ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Liver fatty acid-binding protein (L-FABP) is a small cytoplasmic molecule highly expressed in the liver. Since L-FABP exhibits affinities for several biliary components, its presence in bile was explored by Western blotting and competitive ELISA in various mammalian species. A L-FABP-like immunoreactivity was consistently found in both hepatic and gallbladder bile. A close molecular identity between this 14 kDa biliary protein and the purified L-FABP was assessed by immunological analyses and high performance capillary electrophoresis. Pharmacological induction of hepatic L-FABP biosynthesis led to a similar increase in biliary L-FABP levels showing a close relationships between the cytosolic and biliary contents of this protein. Finally, a correlation between the presence of L-FABP in bile and both bile flow and bile acid release was found. These data suggest an output of L-FABP in bile in normal conditions which might be coupled with the physiological release of biliary components.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Dijon</li><li>Marseilles</li></settlement></list><tree><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Foucaud, Laurent" sort="Foucaud, Laurent" uniqKey="Foucaud L" first="Laurent" last="Foucaud">Laurent Foucaud</name></region><name sortKey="Besnard, Philippe" sort="Besnard, Philippe" uniqKey="Besnard P" first="Philippe" last="Besnard">Philippe Besnard</name><name sortKey="Besnard, Philippe" sort="Besnard, Philippe" uniqKey="Besnard P" first="Philippe" last="Besnard">Philippe Besnard</name><name sortKey="Domingo, Nicole" sort="Domingo, Nicole" uniqKey="Domingo N" first="Nicole" last="Domingo">Nicole Domingo</name><name sortKey="Grillasca, Joel" sort="Grillasca, Joel" uniqKey="Grillasca J" first="Joël" last="Grillasca">Joël Grillasca</name><name sortKey="Lafont, Huguette" sort="Lafont, Huguette" uniqKey="Lafont H" first="Huguette" last="Lafont">Huguette Lafont</name><name sortKey="Niot, Isabelle" sort="Niot, Isabelle" uniqKey="Niot I" first="Isabelle" last="Niot">Isabelle Niot</name><name sortKey="Planells, Richard" sort="Planells, Richard" uniqKey="Planells R" first="Richard" last="Planells">Richard Planells</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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